[Interrelation of the processes of lipid peroxidation and hydroxylation in the liver microsomal fraction of white rats with alloxan diabetes]

Autor:	K G, Karagezian, L M, Ovsepian, K G, Adonts
Rok vydání:	1985
Předmět:	Lipid Peroxides Cytochrome P-450 Enzyme System Microsomes Liver Animals Hydroxylation Oxidation-Reduction Diabetes Mellitus Experimental Rats
Zdroj:	Voprosy meditsinskoi khimii. 31(2)
ISSN:	0042-8809
Popis:	Alloxan diabetes was accompanied by an increase in ascorbate-NADPH-dependent lipid peroxidation with a simultaneous decrease in content of cytochrome P-450 and in the rate aniline hydroxylation in rat liver microsomal fraction. Activation of lipid peroxidation, which led to impairment of the endoplasmic reticulum integrity as well as to destruction of cytochrome P-450, may be important in pathogenesis of alloxan diabetes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::42378bf2ebb972384ddae33da749f6fd https://pubmed.ncbi.nlm.nih.gov/4002660 Zobrazit plný text záznamu