[Experimental study of the action of the RNAse from Actinomyces rimosus on the variolovaccine virus]

Autor:	T Ia, Goncharskaia, G A, Penzikova, L V, Umnova
Rok vydání:	1979
Předmět:	Ribonucleases Time Factors Virus Cultivation Dose-Response Relationship Drug Animals Chick Embryo Variola virus Antiviral Agents Streptomyces
Zdroj:	Antibiotiki. 24(3)
ISSN:	0003-5637
Popis:	The effect of Actinomyces rimosus RNAase on the variolovaccine virus was studied. The inhibitory effect of the Actinomyces rimosus RNAase on the variolovaccine virus reproduction in the tissue culture cells was shown. In the experiments with the use of chick embryons and rabbits this effect was less pronounced. A 10 time increase in the infection multiplicity both in the tissue culture and the chick embryons had no noticeable effect on the level of the virus inhibition. It was supposed that the inhibitory effect of the RNAase on the variolovaccine was associated with impairment of the cell metabolism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::42340ce774f1ceddace212c60e4aa2e5 https://pubmed.ncbi.nlm.nih.gov/220906 Zobrazit plný text záznamu