TSPAN6 is a suppressor of Ras-driven cancer

Autor:	Patrick O, Humbert, Tamara Zoranovic, Pryjda, Blanka, Pranjic, Andrew, Farrell, Kohei, Fujikura, Ricardo, de Matos Simoes, Rezaul, Karim, Ivona, Kozieradzki, Shane J F, Cronin, G Gregory, Neely, Thomas F, Meyer, Astrid, Hagelkruys, Helena E, Richardson, Josef M, Penninger
Rok vydání:	2020
Předmět:	Mammals Pancreatic Neoplasms Proto-Oncogene Proteins p21(ras) Mice Cell Transformation Neoplastic Genes ras Carcinogenesis Tetraspanins Cell Line Tumor Mutation Animals Humans Oncogenes
Zdroj:	Oncogene. 41(14)
ISSN:	1476-5594
Popis:	Oncogenic mutations in the small GTPase RAS contribute to ~30% of human cancers. In a Drosophila genetic screen, we identified novel and evolutionary conserved cancer genes that affect Ras-driven tumorigenesis and metastasis in Drosophila including confirmation of the tetraspanin Tsp29Fb. However, it was not known whether the mammalian Tsp29Fb orthologue, TSPAN6, has any role in RAS-driven human epithelial tumors. Here we show that TSPAN6 suppressed tumor growth and metastatic dissemination of human RAS activating mutant pancreatic cancer xenografts. Whole-body knockout as well as tumor cell autonomous inactivation using floxed alleles of Tspan6 in mice enhanced Kras
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::420c4b0b406975282c7e1f40a85148bd https://pubmed.ncbi.nlm.nih.gov/35292775 Zobrazit plný text záznamu Full text from SpringerLink