[Early improvement in Type 2 diabetes in obese patients following gastric bypass and bilio-pancreatic diversion: the role of the entero-insular axis]
| Autor: | J-C, Lifante, W-B, Inabnet |
|---|---|
| Jazyk: | francouzština |
| Rok vydání: | 2008 |
| Předmět: |
Leptin
Clinical Trials as Topic Time Factors Gastric Bypass Gastric Inhibitory Polypeptide Biliopancreatic Diversion Incretins Body Mass Index Diabetes Mellitus Experimental Obesity Morbid Rats Treatment Outcome Adipokines Diabetes Mellitus Type 2 Glucagon-Like Peptide 1 Case-Control Studies Weight Loss Animals Humans Macaca Adiponectin Follow-Up Studies |
| Zdroj: | Journal de chirurgie. 145(6) |
| ISSN: | 0021-7697 |
| Popis: | Improvement in Type 2 diabetes is seen in 80-98% of obese diabetic patients who undergo gastric bypass or bilio-pancreatic diversion. This improvement is evident early after the operation before significant weight loss has occurred. Although numerous teams have extensively studied the physiology of this early post-bypass amelioration of type 2 diabetes, the exact mechanism of diabetes remission remains unclear. Studies have focused on changes in the entero-insular axis, which is mediated in part by the interaction of insulinotropic hormones GIP and GIP 1 on the beta islet cells of the pancreas. Other mechanisms which have been postulated focus on the adipo-insular axis; the actions of adiponectin and leptin seem to have an important role in insulin resistance but their action is weight-loss dependent. Post-operative caloric restriction may also contribute to the early resolution of type 2 diabetes observed after gastric bypass and bilio- pancreatic diversion. |
| Databáze: | OpenAIRE |
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