| Autor: |
A M, Dhople, L C, Lamoureux, G D, Gardner |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Indian journal of leprosy. 63(2) |
| ISSN: |
0254-9395 |
| Popis: |
Interactions of different drugs commonly used in multiple drug therapy were evaluated using both in vitro culture (cell-free as well as macrophage) system and mouse footpad. No additive effects were obtained in the in vitro system when dapsone was combined with either rifampicin or clofazimine, while a strong antagonism was observed when clofazimine was combined with rifampicin but not with rifabutin. In the mouse footpad system, a strong synergism was obtained when clofazimine was combined with either rifampicin or rifabutin, but significant antagonism was observed with the combination of clofazimine and dapsone. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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