| Autor: |
Oughtred, Rose, Chatr-aryamontri, Andrew, Breitkreutz, Bobby-Joe, Chang, Christie S., Rust, Jennifer M., Theesfeld, Chandra L., Heinicke, Sven, Breitkreutz, Ashton, Chen, Daici, Hirschman, Jodi, Kolas, Nadine, Livstone, Michael S., Nixon, Julie, O’Donnell, Lara, Ramage, Lindsay, Winter, Andrew, Reguly, Teresa, Sellam, Adnane, Stark, Chris, Boucher, Lorrie, Dolinski, Kara, Tyers, Mike |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Popis: |
The Biological General Repository for Interaction Datasets (BioGRID; www.thebiogrid.org) is a freely available public database that provides the biological and biomedical research communities with curated protein and genetic interaction data. Structured experimental evidence codes, an intuitive search interface and visualization tools enable the discovery of individual gene, protein or biological network function. BioGRID houses interaction data for the major model organism species - including yeast, nematode, fly, zebrafish, mouse and human - with particular emphasis on the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe as pioneer eukaryotic models for network biology. BioGRID has achieved comprehensive curation coverage of the entire literature for these two major yeast models, which is actively maintained through monthly curation updates. As of December 2014, BioGRID houses approximately 349,000 biological interactions for budding yeast, and 69,700 interactions for fission yeast. BioGRID also supports an integrated post-translational modification (PTM) viewer that incorporates over 20,100 yeast phosphorylation sites curated through its sister database, the PhosphoGRID (www.phosphogrid.org). This protocol describes how to use the BioGRID website to query genetic or protein interactions for any gene of interest, how to visualize the associated interactions using an embedded interactive network viewer, and how to download data files for either selected interactions or the entire BioGRID interaction data set. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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