From DNA structure to gene expression: mediators of nuclear compartmentalization and dynamics

Autor:	J, Bode, S, Goetze, H, Heng, S A, Krawetz, C, Benham
Rok vydání:	2003
Předmět:	Models Genetic Gene Expression Nuclear Matrix Matrix Attachment Region Binding Proteins Matrix Attachment Regions Chromatin Lamins
Zdroj:	Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 11(5)
ISSN:	0967-3849
Popis:	Eukaryotic genomes are functionally compartmentalized into chromatin domains by their attachment to a supporting structure that has traditionally been termed the nuclear matrix. Present evidence indicates the dynamics of this entity, which requires particular properties of the elements that mediate this kind of interaction. Above all, this is enabled by the so-called 'mass binding phenomenon' by which scaffold/matrix-attachment regions (S/MARs) reversibly associate with ubiquitous factors. Recent investigations and novel techniques have shown that these contacts can be altered by modulators as well as by specific interactions with the components of enhancers and locus control regions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::41d59fb3016d346d5b66c3168b4ff088 https://pubmed.ncbi.nlm.nih.gov/12971720 Zobrazit plný text záznamu Full text from SpringerLink