Urinary uromodulin independently predicts end-stage renal disease and rapid kidney function decline in a cohort of chronic kidney disease patients
| Autor: | Dominik, Steubl, Matthias, Block, Victor, Herbst, Wolfgang Andreas, Nockher, Wolfgang, Schlumberger, Stephan, Kemmner, Quirin, Bachmann, Susanne, Angermann, Ming, Wen, Uwe, Heemann, Lutz, Renders, Pranav S, Garimella, Jürgen, Scherberich |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male uromodulin Observational Study predictor Kidney Kidney Function Tests decline Cohort Studies Predictive Value of Tests Risk Factors CKD eGFR Humans Tamm–Horsfall protein Renal Insufficiency Chronic ESRD Aged Proportional Hazards Models Middle Aged Proteinuria ROC Curve Area Under Curve Multivariate Analysis ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Disease Progression Kidney Failure Chronic biomarker Female Glomerular Filtration Rate Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Supplemental Digital Content is available in the text Data on risk factors predicting rapid progression to end-stage renal disease (ESRD) or short-term kidney function decline (i.e., within 1 year) in chronic kidney disease (CKD) are rare but urgently needed to plan treatment. This study describes the association and predictive value of urinary uromodulin (uUMOD) for rapid progression of CKD. We assessed uUMOD, demographic/treatment parameters, estimated glomerular filtration rate (eGFR), and proteinuria in 230 CKD patients stage I-V. ESRD and 25% decline of eGFR was documented at the end of follow-up period and used as a composite endpoint. Association between logarithmic uUMOD and eGFR/proteinuria was calculated using linear regression analysis, adjusting for age, gender, and body mass index. We performed multivariable Cox proportional hazard regression analysis to evaluate the association of uUMOD with the composite endpoint. Therefore, patients were categorized into quartiles. The predictive value of uUMOD for the above outcomes was assessed using receiver-operating characteristic (ROC) curve analysis. Follow-up was 57.3 ± 18.7 weeks, baseline age was 60 (18;92) years, and eGFR was 38 (6;156) mL/min/1.73 m2. Forty-seven (20.4%) patients reached the composite endpoint. uUMOD concentrations were directly associated with eGFR and inversely associated with proteinuria (β = 0.554 and β = -0.429, P |
| Databáze: | OpenAIRE |
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