Use of aminoglutethimide for the treatment of advanced breast cancer. Clinical correlations with previous treatment, oestrogen-receptor and menstrual status

Autor:	W R, Bezwoda, R D, Dansey, C S, Hesdorffer, S, Browde
Rok vydání:	1987
Předmět:	Hydrocortisone Receptors Estrogen Evaluation Studies as Topic Antineoplastic Combined Chemotherapy Protocols Humans Breast Neoplasms Female Menopause Aminoglutethimide
Zdroj:	South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 72(2)
ISSN:	0256-9574
Popis:	In a study of 118 patients with advanced breast cancer treated with aminoglutethimide plus hydrocortisone replacement the overall objective response rate was 42 (36%). Response was not determined either by the nature or the extent of previous treatment, including endocrine therapy and/or chemotherapy, nor by oestrogen-receptor status. The vast majority of patients who responded were postmenopausal but a complete response was seen in a premenopausal patient with skin metastases. Aminoglutethimide is useful in the second-line treatment of postmenopausal subjects with advanced breast cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::417cd21c0438e0212c71793047f848c7 https://pubmed.ncbi.nlm.nih.gov/3616780 Zobrazit plný text záznamu