Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart☆

Autor: Ward, Matthew, Iskratsch, Thomas
Jazyk: angličtina
Rok vydání: 2020
Předmět:
ICM
Idiopathic cardiomyopathy
HLCCs
Hylald-derived collagen crosslinks
HCM
hypertrophic cardiomyopathy
Heart Diseases
DCM
Dilated cardiomyopathy
PKC
Protein Kinase C
GEF
Guanine nucleotide exchange factor
LV
Left ventricle
MRTF
myocardin-related transcription factor
Mechanotransduction
Cellular
Article
VASH1
vasohibin-1
LCCs
Lysald-derived collagen crosslinks
LH
Lysyl hydroxylase
PKA
Protein Kinase A
Humans
Myocytes
Cardiac
MRE
magnetic resonance elastography
Cell Proliferation
TNNT
Troponin T
SWE
ultrasound cardiac shear-wave elastography
Cell Death
LOX
Lysyl oxidase
TCP
tubulin carboxypeptidase
SVBP
small vasohibin binding protein
Lys
Lysin
Cell Differentiation
Heart
TNNI
Troponin I
AFM
atomic force microscope
LOXL
Lysyl oxidase like protein
CM
Cardiomyocytes
MYH
Myosin Heavy Chain
TTL
tubulin tyrosine ligase
Cellular Microenvironment
GAP
GTPase activating protein
Zdroj: Biochimica et Biophysica Acta. Molecular Cell Research
ISSN: 1879-2596
0167-4889
Popis: The composition and the stiffness of cardiac microenvironment change during development and/or in heart disease. Cardiomyocytes (CMs) and their progenitors sense these changes, which decides over the cell fate and can trigger CM (progenitor) proliferation, differentiation, de-differentiation or death. The field of mechanobiology has seen a constant increase in output that also includes a wealth of new studies specific to cardiac or cardiomyocyte mechanosensing. As a result, mechanosensing and transduction in the heart is increasingly being recognised as a main driver of regulating the heart formation and function. Recent work has for instance focused on measuring the molecular, physical and mechanical changes of the cellular environment - as well as intracellular contributors to the passive stiffness of the heart. On the other hand, a variety of new studies shed light into the molecular machinery that allow the cardiomyocytes to sense these properties. Here we want to discuss the recent work on this topic, but also specifically focus on how the different components are regulated at various stages during development, in health or disease in order to highlight changes that might contribute to disease progression and heart failure.
Highlights • The stiffness of the heart changes during development or in disease. • These changes influence cardiomyocyte behaviour and function. • Various intra- and extracellular elements contribute to the stiffness. • The molecules and pathways that are sensing the stiffness are changing as well.
Databáze: OpenAIRE
Externí odkaz: