| Autor: |
M N, Chiano, D G, Clayton |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
Genetic epidemiology. 15(2) |
| ISSN: |
0741-0395 |
| Popis: |
In mapping diseases of complex aetiology, conventional linkage approaches narrow the location of the disease susceptibility locus to quite a large region so that candidate gene association studies are then necessary to further isolate these genes. However, even in the simplest scenario where the candidate locus is bi-allelic, two statistical tests with various correcting factors have been proposed: a chi-square 1 df test (counting chromosomes) which may be slightly conservative and a 2 df chi-square test (counting genotypes) which may lack power because of the extra degree of freedom. This paper introduces a better and more powerful alternative which turns out to be a compromise between the two existing statistical tests. The asymptotic distribution of this test statistic is determined and the efficacy of the 3 tests are compared under different genetic models by simulation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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