In Vivo Tracking of the Degradation of Mesoporous Silica through

Autor:	Elisa, Bindini, Maria de Los Angeles, Ramirez, Xabier, Rios, Unai, Cossío, Cristina, Simó, Vanessa, Gomez-Vallejo, Galo, Soler-Illia, Jordi, Llop, Sergio E, Moya
Rok vydání:	2021
Předmět:	Drug Delivery Systems Nanoparticles Tissue Distribution Silicon Dioxide Porosity
Zdroj:	Small (Weinheim an der Bergstrasse, Germany). 17(30)
ISSN:	1613-6829
Popis:	While mesoporous silica nanoparticles (MSNs) are extensively studied as high-potential drug delivery platforms, the successful clinical translation of these nanocarriers strongly depends on their biodistribution, biodegradation, and elimination patterns in vivo. Here, a novel method is reported to follow the in vivo degradation of MSNs by tracking a radioactive label embedded in the silica structure. Core-shell silica nanoparticles (NPs) with a dense core and a mesoporous shell are labeled with low quantities of the positron emitter
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::416ea9ae3f7101a10a27e6ae7c17fa6c https://pubmed.ncbi.nlm.nih.gov/34145769 Zobrazit plný text záznamu Plný text