Vitronectin significantly influences prognosis in osteosarcoma
| Autor: | Kai, Shi, Rui-Long, Lan, Xuan, Tao, Chao-Yang, Wu, Hai-Feng, Hong, Jian-Hua, Lin |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Time Factors Adolescent Bone Neoplasms Kaplan-Meier Estimate Disease-Free Survival Young Adult Predictive Value of Tests Risk Factors Biomarkers Tumor Humans Vitronectin Child Aged Proportional Hazards Models Osteosarcoma Chi-Square Distribution Chemoradiotherapy Adjuvant Middle Aged Immunohistochemistry Neoadjuvant Therapy Tumor Burden Up-Regulation Treatment Outcome Multivariate Analysis Disease Progression Female Original Article |
| Zdroj: | International journal of clinical and experimental pathology. 8(9) |
| ISSN: | 1936-2625 |
| Popis: | Vitronectin (Vn), a multifunctional adhesive protein, is found in association with tumor progression, angiogenesis and metastasis in a variety of (human) tumors. But no studies concerning its correlation to osteosarcoma prognosis were found. Hence, we aimed to investigate the prognostic value of Vitronectin (Vn) in osteosarcoma. Here, we studied the expression of VN in the tumor tissues from 67 patients with osteosarcoma and 20 patients with osteochondroma using immunohistochemistry and estimated the effects of VN expression in osteosarcoma on progression-free survival (PFS) and overall survival (OS) using the Kaplan-Meier curve and COX proportional hazards regression model. Increased expression of VN in osteosarcoma tissue compared to no VN expression in osteochondroma tissue was shown in immunohistochemical assay. No associations were observed between VN expression and osteosarcoma patients’ gender (P = 0.675), age (P = 0.813), tumor size (P = 0.436), histologic subtype (P = 0.0.543) or tumor location (P = 0.456). Univariate survival analysis demonstrated significant correlations of high VN expression with shorter PFS (P = 0.002) and OS (P = 0.001); multivariate survival analysis revealed high VN expression as a significant independent prognostic indicator for shorter PFS (HR 2.788, P = 0.003) and OS (HR2.817, P = 0.003). In conclusion, the high expression of VN in tumor cells independently indicated poor clinical prognosis in patients with osteosarcoma, other than large tumor size and non-neoadjuvant chemoradiotherapy, suggesting that VN may serve as a potential therapeutic target in osteosarcoma. |
| Databáze: | OpenAIRE |
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