| Autor: |
G I, Klebanov, O B, Liubitskiĭ, O V, Vasil'eva, Iu V, Klimov, O B, Penzulaeva, A S, Tepliashin, M P, Tolstykh, V K, Promorenko, Iu A, Vladimirov |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Voprosy meditsinskoi khimii. 47(3) |
| ISSN: |
0042-8809 |
| Popis: |
Using three chemiluminescent model systems of oxidation (suspension of phospholipid liposomes, a geous solution of haemoglobin-hydrogen peroxide-luminol and a geous solution 2,2'-azo-bis-(2-methylpropionamidine)dihydrochloride-luminol) the antioxidant activity and mechanism of antioxidant action of three 3-oxypyridine analogues: (mexidol, emoxipin and proxipin) were studied. These compounds were shown: a) to interact with catalitically active two valency iron ions (Fe2+), that causes elimination of ions from the model system; b) to scavenge reactive oxygen species and/or luminol radicals produced in the model systems. Their activity reduced in the following order: mexidolemoxipinproxipin. The antioxidant activity of 3-oxypyridines may underline known clinical effects of these compounds. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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