Post cardiac transplantation lymphoproliferative disorder presenting as t(8;14) Burkitt leukaemia/lymphoma treated with low intensity chemotherapy and rituximab

Autor:	Kevin, Windebank, Tom, Walwyn, Richard, Kirk, Gareth, Parry, Asif, Hasan, Nick, Bown, Bridget, Wilkins
Rok vydání:	2009
Předmět:	Chromosomes Human Pair 14 Male Adolescent Antibodies Monoclonal Infant Burkitt Lymphoma Translocation Genetic Antibodies Monoclonal Murine-Derived Child Preschool Antineoplastic Combined Chemotherapy Protocols Heart Transplantation Humans Female Child Rituximab Chromosomes Human Pair 8
Zdroj:	Pediatric bloodcancer. 53(3)
ISSN:	1545-5017
Popis:	Post-transplant lymphoproliferative disorder (PTLD) occasionally presents as Burkitt lymphoma/L3 leukaemia (BLL).We reviewed records of cases of PTLD post-cardiac transplantation (1990-2007) occurring in our unit.There were 15 episodes in 13 patients including four cases of EBV-driven Burkitt-type disease with t(8;14) translocations presenting with advanced stage disease. The first case was treated with a variety of low dose chemotherapy combinations. Despite problems during therapy he obtained complete remission, but died from complications of pre-existing cardiac allograft vasculopathy 7 months later. The subsequent three cases were treated with a UKCCSG low stage lymphoma protocol, NHL 9001 and Rituximab. They remain in complete remission.In the context of PTLD the prognostic significance of advanced stage EBV-driven BLL with the t(8;14) translocation may be different to that in immunocompetent children.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::41103ac373aef426e0859d324754e8f2 https://pubmed.ncbi.nlm.nih.gov/19459198 Zobrazit plný text záznamu Plný text