| Autor: |
Jennifer A, Fitzgerald, Hannah M, Jameson, Victoria H Dewar, Fowler, Georgia L, Bond, Lisa K, Bickley, Tamsyn M Uren, Webster, Nic R, Bury, Robert J, Wilson, Eduarda M, Santos |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Environmental sciencetechnology. 50(8) |
| ISSN: |
1520-5851 |
| Popis: |
Hypoxia is a global and increasingly important stressor in aquatic ecosystems, with major impacts on biodiversity worldwide. Hypoxic waters are often contaminated with a wide range of chemicals but little is known about the interactions between these stressors. We investigated the effects of hypoxia on the responses of zebrafish (Danio rerio) embryos to copper, a widespread aquatic contaminant. We showed that during continuous exposures copper toxicity was reduced by over 2-fold under hypoxia compared to normoxia. When exposures were conducted during 24 h windows, hypoxia reduced copper toxicity during early development and increased its toxicity in hatched larvae. To investigate the role of the hypoxia signaling pathway on the suppression of copper toxicity during early development, we stabilized the hypoxia inducible factor (HIF) pathway under normoxia using a prolyl-4-hydroxylase inhibitor, dimethyloxalylglycine (DMOG) and demonstrated that HIF activation results in a strong reduction in copper toxicity. We also established that the reduction in copper toxicity during early development was independent of copper uptake, while after hatching, copper uptake was increased under hypoxia, corresponding to an increase in copper toxicity. These findings change our understanding of the current and future impacts of worldwide oxygen depletion on fish communities challenged by anthropogenic toxicants. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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