| Autor: |
J, Maral, M, Steinberg, M, Weil, C, Chleq, D, Khayat, P, Banzet, C, Jacquillat |
| Jazyk: |
francouzština |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
Presse medicale (Paris, France : 1983). 16(21) |
| ISSN: |
0755-4982 |
| Popis: |
Twenty-two patients with metastatic malignant melanoma received either 36 X 10(6) U (15 patients) or 18 X 10(6) U (7 patients) of human recombinant interferon alpha-2-A daily for 3 months by the intramuscular route, with progressive increase of dosage. This was followed in responders by a maintenance treatment consisting of 3 intramuscular injections per week in the same doses as those received at the end of the induction treatment. Out of 18 patients assessable for effectiveness, 1 had complete remission (7 months +) and 3 had partial response (52,61 and 82 days respectively), an overall improvement rate of 22%. The main side-effects observed were: pseudoinfluenza syndrome (100%), fatigue (100%), somnolence (95%), anorexia (90%) and haematological disorders. Dosage reduction was necessary in 13 of the 15 patients receiving 36 MU. This study shows that human recombinant interferon alpha-2-A has antitumoral activity in metastatic malignant melanoma. Other studies, notably with therapeutic combinations, are needed to determine the optimal dosage regimen of the drug and to increase its effectiveness. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
