6-Nitrochrysene-Derived C8-2'-Deoxyadenosine Adduct: Synthesis of Site-Specific Oligodeoxynucleotides and Mutagenicity in
| Autor: | Brent V, Powell, Ashis K, Basu |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Chemical research in toxicology. 33(2) |
| ISSN: | 1520-5010 |
| Popis: | 6-Nitrochrysene (6-NC), the most potent carcinogen evaluated by the newborn mouse assay, is metabolically activated by nitroreduction and a combination of ring oxidation and nitroreduction pathways. The nitroreduction pathway yields three major DNA adducts: at the C8 and |
| Databáze: | OpenAIRE |
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