| Autor: |
V L, Kolodkina, E V, Fel'dman, A M, Dronina, L P, Titov, A K, Kozhemiakin, D F, Zakharenko |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Zhurnal mikrobiologii, epidemiologii i immunobiologii. (4) |
| ISSN: |
0372-9311 |
| Popis: |
The outbreak of diphtheria in the Republic of Belarus developed in the presence of a sharp deficiency of immunity among the population aged 35 years and over. In connection with a higher initial immunity level resulting from vaccination made in one injection the minimum antibody level (or = 0.01 I.U./ml) was found in 79.7% of the examinees among the population under 35 years. For the age group of 35-60 years vaccination in one and two injections proved to be insufficiently effective (the minimum protective antibody titer was found, respectively, in 64.3% and 63.3% of the vaccinees). To achieve the full protection of this group of the population, vaccination in three injections was necessary; after that the minimum protective antibody titer was found in 90.7%, the protective antibody titer (0.1 I.U./ml) was found in 53.5% and the highly protective antibody titer (1.0 I.U./ml) was found in 11.6% of the examinees. The low level of highly protected persons among vaccinees receiving three injections was due to a low dose of diphtheria toxoid (2 Lf) in adsorbed DT-m vaccine with reduced antigen content. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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