| Autor: |
M M, Seredenko, V K, Rybal'chenko, T M, Hovorukha, A I, Nazarenko, H B, Fil', V M, Baban |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). 49(1) |
| ISSN: |
2522-9028 |
| Popis: |
Effects of N-oxide 2,6-dimetilpyridine (ivin) on the intensity of lipid peroxidation (in vivo and in vitro), microsomal hydroxylation and secretion of the bile (in vivo) were investigated. It has been shown that the preparation did not act significantly on the rate of lipid peroxidation in the liver homogenates both in vivo (5 mg/100 g, 4 weeks) and in vitro (10(-6)-10(-2) mol, incubation). Ivin did not change the activity of the microsomal hydroxylation (hexenal), but stimulated the excretion of biliary organic and inorganic components. The role of NO as a transmitter for effects of N-oxide 2,6-dimetilpyridine and the possibility of its influence on the processes under exploration via the modification of the structure of a biomembrane have being discussed to be one of the basic mechanisms. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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