| Autor: |
M J, Ernest, L, DeLap, P, Feigelson |
| Rok vydání: |
1978 |
| Předmět: |
|
| Zdroj: |
The Journal of biological chemistry. 253(9) |
| ISSN: |
0021-9258 |
| Popis: |
Several protein synthesis inhibitors were as effective as the inducers hydrocortisone or cyclic AMP in elevating rat liver tyrosine aminotransferase mRNA levels when assayed in the wheat germ cell-free translational system. Cycloheximide, emetine, or puromycin increased this mRNA activity 6- to 7-fold within 4 h after in vivo administration. No increase in total hepatic mRNA levels or tryptophan oxygenase mRNA was found after treatment with these protein synthesis inhibitors. Furthermesults suggest that a short lived protein may specifically regulate the level of functional hepatic tyrosine aminotransferase mRNA or that ongoing translation of this mRNA is required for its degradation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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