| Autor: |
Y P, Wong, A, Yahaya, R, Che Abdul Aziz, P Y, Chia, C K, Loh, G C, Tan |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
The Malaysian journal of pathology. 42(2) |
| ISSN: |
0126-8635 |
| Popis: |
Yolk sac tumour (YST) or endodermal sinus tumour is rare and typically seen in gonads.We described a case of extragonadal vaginal YST in a one year and seven months old girl who presented with vaginal discharge and bleeding, and discuss its differential diagnosis and potential pitfalls in immunohistochemistry. She was found to have a suprapubic mass on examination. The serum alpha fetoprotein was 11919.4 ng/mL. Computed tomography of the pelvis revealed a large 6.4 cm heterogenous pelvic mass. Colposcopic examination of the pelvis showed a fungating vaginal mass that was subsequently confirmed as a yolk sac tumour. Immunohistochemically, the malignant cells were positive toward CKAE1/AE3, AFP and glypican-3, as well as CD117.Solid pattern extragonadal vaginal YST may morphologically resemble dysgerminoma that is also CD117 positive, while the glandular pattern YST may have clear cytoplasm and is positive for cytokeratin; hence, may resemble clear cell carcinoma. Being mindful of these potential diagnostic caveats is necessary to prevent misdiagnosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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