In Silico Study of Plant Polyphenols' Interactions with VP24-Ebola Virus Membrane-associated Protein

Autor: Sebastian, Pleško, Helena, Volk, Miha, Lukšič, Črtomir, Podlipnik
Rok vydání: 2015
Předmět:
Zdroj: Acta chimica Slovenica. 62(3)
ISSN: 1318-0207
Popis: The Zaire Ebola viral protein VP24 selectively inhibits nuclear import of STAT1 and as such blocks interferon-induced antiviral responses vital for cell's emergency. Inhibition of VP24 with small molecule inhibitor may neutralize the threatening action of Ebola virus. We performed molecular docking of compounds from a selected small library of plant polyphenols on to VP24. Our research shows that 1,2,3,6-tetragalloyl glucose, epigallocatechin gallate, chlorogenic acic, oleuropein and miquelianin represent promising leads for further studies.
Databáze: OpenAIRE