Multidrug resistance-associated protein gene expression and drug sensitivity in human lung cancer cells

Autor:	F, Narasaki, M, Oka, M, Fukuda, K, Ikeda, K, Terashi, H, Takatani, T, Nakamura, H, Soda, S, Kohno
Rok vydání:	1997
Předmět:	Lung Neoplasms Drug Resistance Multiple Gene Expression Regulation Neoplastic Verapamil Doxorubicin Vincristine Tumor Cells Cultured Humans ATP-Binding Cassette Transporters RNA Messenger Cisplatin Genes MDR Multidrug Resistance-Associated Proteins Etoposide
Zdroj:	Anticancer research. 17(5A)
ISSN:	0250-7005
Popis:	Multidrug resistance-associated protein (MRP) mRNA expression and drug sensitivity in lung cancer cells were examined, and the effects of verapamil, a modulating agent for MRP, on drug sensitivity were also tested. Nine cell lines expressed various levels of MRP gene expression but not the MDR1 gene. The levels were higher in non-small cell carcinoma cells (NSCLC) than in small cell carcinoma cells (SCLC). Clear correlations between the MRP gene level and the sensitivity to etoposide (VP-16) and doxorubicin (Dox) were observed except for one cell line which highly expressed DNA topoisomerase II. Positive correlations between the MRP gene levels in three cell lines and the modulation effects of verapamil in VP-16, Dox, and vincristine were observed. The present results indicate that MRP probably confers intrinsic multidrug resistance in NSCLC rather than in SCLC.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::40181c1933f44a52c5c1542249e1eed8 https://pubmed.ncbi.nlm.nih.gov/9413193 Zobrazit plný text záznamu