| Autor: |
Ming, Ni, Ze-Hua, Zhu, Feng, Gao, Lin-Bin, Dai, Xin-Yi, Lv, Qiong, Wang, Xing-Xing, Zhu, Ji-Kui, Xie, Yong, Shen, Shi-Cun, Wang, Qiang, Xie |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
ACS chemical neuroscience. 14(1) |
| ISSN: |
1948-7193 |
| Popis: |
Blood-based biomarkers have been considered as a promising method for the diagnosis of Alzheimer's disease (AD). The reliability and accuracy of plasma core AD biomarkers, including phosphorylated tau (P-tau181), total tau (T-tau), Aβ42, and Aβ40, have also been confirmed in diagnosing AD and predicting cerebral β-amyloid (Aβ) deposition in Western populations, while fewer research studies have ever been conducted in China's Han population. In this study, we investigated the capability of plasma core AD biomarkers in predicting cerebral Aβ deposition burden among the China Aging and Neurodegenerative Disorder Initiative (CANDI) cohort consisting of cognitively normal (CN), mild cognitive impairment (MCI), AD dementia, and non-Alzheimer's dementia disease (Non-ADD). Body fluid (plasma and CSF) AD core biomarkers were measured via single-molecule array (Simoa) immunoassay. The global standard uptake value ratio (SUVR) was then calculated by |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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