| Autor: |
E M, O'Byrne, V J, Blancuzzi, D E, Wilson, M, Wong, J, Peppard, J P, Simke, A Y, Jeng |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
International journal of tissue reactions. 12(1) |
| ISSN: |
0250-0868 |
| Popis: |
Inflammation was induced by intra-articular injection of 100 ng recombinant human interleukin-1 alpha (rhIL-1) into rabbit knees. Substance P (SP) and prostaglandin E2 (PGE2) were measured by radioimmunoassay (RIA) in the joint fluid at 4, 24 and 48 h after rhIL-1 injection. SP was increased by 4 h, further increased at 24 h and remained elevated at 48 h. PGE2 concentration was highest at 4 h and remained elevated at 48 h after rhIL-1 injection. Because of the proinflammatory activities of SP and PGE2, our studies suggest that the elevated SP and PGE2, in the joint may amplify or sustain an initial receptor-mediated inflammatory response to IL-1. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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