Identification of the INO1 gene of Mycobacterium tuberculosis H37Rv reveals a novel class of inositol-1-phosphate synthase enzyme

Autor:	N, Bachhawat, S C, Mande
Rok vydání:	1999
Předmět:	Models Molecular Binding Sites Sequence Homology Amino Acid Genes Bacterial Protein Conformation Molecular Sequence Data Myo-Inositol-1-Phosphate Synthase Amino Acid Sequence Mycobacterium tuberculosis NADP
Zdroj:	Journal of molecular biology. 291(3)
ISSN:	0022-2836
Popis:	1L-myo-inositol (inositol) is vital for the biogenesis of mycothiol, phosphatidylinositol and glycosylphosphatidylinositol anchors linked to complex carbohydrates in Mycobacterium tuberculosis. All these cellular components are thought to play important roles in host-pathogen interactions and in the survival of the pathogen within the host. However, the inositol biosynthetic pathway in M. tuberculosis is not known. To delineate the pathways for inositol formation, we employed a unique combination of tertiary structure prediction and yeast-based functional assays. Here, we describe the identification of the gene for mycobacterial INO1 that encodes inositol-1-phosphate synthase distinct in many respects from the eukaryotic analogues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::3fc5de2490574e669f228dcbc28a35b7 https://pubmed.ncbi.nlm.nih.gov/10448034 Zobrazit plný text záznamu Full Text from ScienceDirect