| Autor: |
J, Neu, R L, Ariagno, J D, Johnson, P T, Pitlick, R S, Cohen, C L, Beets, P, Sunshine |
| Rok vydání: |
1981 |
| Předmět: |
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| Zdroj: |
Pediatric pharmacology (New York, N.Y.). 1(3) |
| ISSN: |
0270-322X |
| Popis: |
Over a two year period, 52 infants were found to have clinical signs of patent ductus arteriosus (PDA). Twenty-seven responded to fluid restriction and furosemide; the remaining 25 infants entered the Indomethacin (IN) study protocol. Their mean (+/- SE) gestational age was 29.3 (+/- 0.6) weeks and birth weight was 1,142 (+/- 80) gm. Either a placebo or IN (0.25 mg/kg) orally was given for two doses, 24 hours apart; if no response occurred, the patient was crossed over to the opposite medication. Using Chi-square analysis, a significant response rate to IN was found. There were no significant differences in birth weights, gestational ages, or fluid intake between responders and nonresponders. However, both responders and nonresponders required a prolonged ventilator course, suggesting factors other than PDA causing prolonged ventilatory requirements in these babies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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