| Autor: |
Takeshi, Ebara, Kyoichi, Kaira, Jun-Ichi, Saito, Mariko, Shioya, Takayuki, Asao, Takeo, Takahashi, Hideyuki, Sakurai, Yoshikatsu, Kanai, Hiroyuki, Kuwano, Takashi, Nakano |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Anticancer research. 30(10) |
| ISSN: |
1791-7530 |
| Popis: |
To evaluate whether expression of L-type amino acid transporter 1 (LAT1) in pretreatment rectal cancer biopsies is predictive of tumour response to neoadjuvant hyperthermo-chemoradiotherapy (HCRT).Forty-four patients with rectal adenocarcinoma who received neoadjuvant HCRT were investigated. LAT1 expression was immunohistochemically evaluated using pretreatment biopsies. The operation was performed after 2-3 months following HCRT and each resected specimen was graded by the histological criteria of the Japanese Classification of Colorectal Carcinoma.A positive LAT1 expression was recognized in 50.0% (22/44) of patients. Resected specimens were divided into 2 groups according to the histological grading criteria: good response (n=29) and poor response (n=15). LAT1-negative tumours had an 81.8% probability of good response and 18.2% probability of poor response. LAT1 expression showed marginally significant association with response to HCRT (p=0.05).LAT1 may be a useful predictive marker of response to HCRT in rectal cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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