| Autor: |
Shuzi, Zheng, Chaoqun, Wu, Wei, Yang, Xuanping, Xia, Xiuqing, Lin, Lijia, Jiang, Ran, Ding, Yi, Jiang |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Digestive diseases (Basel, Switzerland). 35(5) |
| ISSN: |
1421-9875 |
| Popis: |
The study aimed to investigate the association of Crohn's disease (CD) with transcobalamin II (TCN2) polymorphisms and serum homocysteine, folate, and vitamin B12 levels.TCN2 (rs1801198, rs9606756) were genotyped by iMLDR in 389 CD patients and 746 controls. Furthermore, 102 CD patients and 153 controls were randomly selected for examination of serum homocysteine, folate, and vitamin B12 levels by enzymatic cycling assay and chemiluminescence immunoassay, respectively.Mutant allele (G) and genotype (AG + GG) of (rs9606756) were higher in CD patients than in controls (both p0.05). So were they in ileocolonic CD patients and stricturing CD patients compared to controls (all p0.05). Mutant allele (G) and genotype (CG + GG) of (rs1801198) were more prevalent in stricturing CD patients than in controls (both p0.05). Compared to controls, average homocysteine level was enhanced in CD patients (p = 0.003), whereas average folate and vitamin B12 levels were reduced in CD patients (both p0.001). The prevalence of hyperhomocysteinemia, folate deficiency, and vitamin B12 deficiency was higher in CD patients than in controls (all p0.01). Both folate deficiency and vitamin B12 deficiency were independently related to risk of CD (both p0.01).TCN2 (rs1801198, rs9606756) polymorphisms as well as folate deficiency and vitamin B12 deficiency are correlated with CD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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