Polycaprolactone and polycaprolactone triol blends to obtain a stable liquid nanotechnological formulation: synthesis, characterization and

Autor:	Juliana, Emanuelli, Viviane, Pagnussat, Katherine, Krieser, Julia, Willig, Andréia, Buffon, Luiz A, Kanis, Stanley, Bilatto, Daniel Souza, Correa, Thaís F, Maito, Sílvia S, Guterres, Adriana R, Pohlmann, Irene C, Külkamp-Guerreiro
Rok vydání:	2021
Předmět:	Pharmaceutical Preparations Polymers Polyesters Taste Humans Saquinavir
Zdroj:	Drug development and industrial pharmacy. 47(10)
ISSN:	1520-5762
Popis:	The use of polymeric blends is a potential strategy to obtain novel nanotechnological formulations aiming at drug delivery systems. Saquinavir, an antiretroviral drug, was chosen as a model drug for the development of new stable liquid formulations with unpleasant taste masking properties. Three formulations containing different polymeric ratios (1:3, 1:1 and 3:1) were prepared and properly characterized by particle size distribution, zeta potential, pH, drug content and encapsulation efficiency measurements. The stability was verified by monitoring the zeta potential, particle size distribution, polydispersity index and drug content by 90 days. The light backscattering analysis was used to early identify possible phenomena of instability in the formulations. The
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::3f72d82792a0ef1997b7025b61a34dba https://pubmed.ncbi.nlm.nih.gov/34821528 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.