Gold Rods Irradiated with Ultrasound for Combination of Hyperthermia and Cancer Chemotherapy
| Autor: | Andre, Barros, Carlos, Austerlitz, Ioannis, Gkigkitzis, Diana, Campos, Jeyce, Andrade, Christina, Peixoto, Jaciana, Aguiar, Silene, Nascimento, Teresinha G, Silva, Ioannis, Haranas |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Mice Inbred BALB C Antibiotics Antineoplastic Hot Temperature Cell Survival Ultrasonic Therapy Hyperthermia Induced Neoplasms Experimental Combined Modality Therapy Microscopy Electron Transmission Ultrasonic Waves Doxorubicin Cell Line Tumor MCF-7 Cells Animals Humans HSP70 Heat-Shock Proteins Gold K562 Cells History Ancient |
| Zdroj: | Advances in experimental medicine and biology. 987 |
| ISSN: | 0065-2598 |
| Popis: | The aim of this study was to analyze feasibility (in vitro and in vivo) the use of hyperthermia produced by gold rods irradiated with ultrasound and their combination with chemotherapy with doxorubicin.initially was determined the cell viability and Hsp70 levels after treatment by gold rods irradiated with ultrasound (GR+U) in cell culture. The pretreatment with GR+U combined with doxorubicin (DOX) was evaluated from ICThe cell viability was completely inhibited after 40 min of treatment with GR+U and significant increases the expression of HSP70 was only observed after 10 min of treatment. GR+U+DOX presented significant reduction of ICThe combined treatment of GR+U and DOX exhibit synergistic characteristics observed by increasing the efficiency of doxorubicin. |
| Databáze: | OpenAIRE |
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