Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: decrease in regional cerebral blood volume in hyperintense subcortical lesions inversely correlates with disability and cognitive performance
| Autor: | R, Bruening, M, Dichgans, C, Berchtenbreiter, T, Yousry, K C, Seelos, R H, Wu, M, Mayer, G, Brix, M, Reiser |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Chromosome Aberrations Male Neurologic Examination Blood Volume Dementia Vascular Brain Chromosome Disorders Cerebral Infarction Syndrome Middle Aged Disability Evaluation Regional Blood Flow Image Processing Computer-Assisted Humans Dementia Female Cerebral Arterial Diseases Dominance Cerebral Mental Status Schedule Aged Genes Dominant |
| Zdroj: | AJNR Am J Neuroradiol |
| ISSN: | 0195-6108 |
| Popis: | BACKGROUND AND PURPOSE: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an arteriopathic syndrome related to a genetic defect on chromosome 19. Characteristic changes in CADASIL can be observed onT2-weighted MR images in the subcortical white matter. The purpose of this study was to measure changes of regional cerebral blood volume (rCBV) with dynamic contrast-enhanced MR imaging and to correlate the changes to disability and cognitive performance. METHODS: We obtained rCBV measurements of 24 individuals with proven CADASIL on a 1.5-T MR imaging unit. A susceptibility-weighted MR imaging sequence was used for bolus tracking. Principles of the indicator dilution theory were applied to estimate values of absolute rCBV (mL/100 g). Disability was determined by using the Rankin scale, and overall cognitive performance was assessed by using the Mini-Mental State Examination. RESULTS: The mean rCBV in the subcortical white matter that was hyperintense on the T2-weighted images (2.7 ± 0.8 mL/100 g) was significantly lower than the rCBV in the white matter that appeared normal on the T2-weighted images (4.4 ± 1.3 mL/100 g) (P < .05). The mean rCBV in the gray matter was within the normal range (8.3 ± 1.7 mL/100 g). Both cognitive impairment and disability negatively correlated with rCBV in the subcortical white matter that was hyperintense (P < .05) but not with rCBV in the normal appearing white matter. rCBV did not correlate with age. CONCLUSION: rCBV measured in the hyperintense subcortical white matter in individuals with CADASIL was decreased and inversely correlated with disability and cognitive impairment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|