Targeting RECQL5 Functions, by a Small Molecule, Selectively Kills Breast Cancer
| Autor: | Saikat, Chakraborty, Kartik, Dutta, Pooja, Gupta, Anubrata, Das, Amit, Das, Sunil Kumar, Ghosh, Birija Sankar, Patro |
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| Rok vydání: | 2021 |
| Předmět: |
Models
Molecular RecQ Helicases Cell Cycle Administration Oral Mice Nude Antineoplastic Agents Breast Neoplasms Xenograft Model Antitumor Assays Gene Expression Regulation Neoplastic Mice Inbred C57BL Gene Knockout Techniques Mice Drug Resistance Neoplasm Cell Line Tumor Animals Humans Computer Simulation Female Cisplatin Drug Screening Assays Antitumor |
| Zdroj: | Journal of medicinal chemistry. 64(3) |
| ISSN: | 1520-4804 |
| Popis: | Clinical and preclinical data reveal that RECQL5 protein overexpression in breast cancer was strongly correlated with poor prognosis, survival, and therapeutic resistance. In the current investigation, we report design, synthesis, and specificity of a small molecule |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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