Post-prophylaxis Toxoplasma chorioretinitis following donor-recipient mismatched liver transplantation
| Autor: | G J, Webb, H, Shah, M D, David, S, Tiew, N, Beare, G M, Hirschfield |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
chorioretinitis Antiprotozoal Agents Toxoplasma gondii Antigens Protozoan Case Report Case Reports Polymerase Chain Reaction ocular Diagnosis Differential Trimethoprim Sulfamethoxazole Drug Combination Humans Transplantation Homologous Serologic Tests Toxoplasmosis Ocular Immunosuppression Therapy disease transmission immunosuppression liver transplantation Antibiotic Prophylaxis Liver Failure Acute Allografts infectious Seroconversion Female Toxoplasma toxoplasmosis |
| Zdroj: | Transplant Infectious Disease |
| ISSN: | 1399-3062 |
| Popis: | Toxoplasmosis may be transferred by organ transplantation. The most common clinical presentation is with multisystem disease, although isolated ocular toxoplasmosis has been described. Many centers have suggested that universal use of co‐trimoxazole prophylaxis obviates the need for specific Toxoplasma testing. We report a case of donor‐acquired ocular toxoplasmosis after liver transplantation despite co‐trimoxazole prophylaxis. The diagnosis was confirmed by Toxoplasma polymerase chain reaction assay in conjunction with seroconversion. The fact that the infection was donor acquired was confirmed by serological mismatch and the absence of sporozoite‐specific antigen antibody in the recipient. |
| Databáze: | OpenAIRE |
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