Conjugation of Zika virus EDIII with CRM
| Autor: | Yunxia, He, Weili, Yu, Lucheng, Xiao, Lijuan, Shen, Jinming, Qi, Tao, Hu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Mice
Inbred BALB C Circular Dichroism Antibody Affinity Viral Vaccines Zika Virus Antibodies Viral Dynamic Light Scattering Polyethylene Glycols Mannans Rats Sprague-Dawley Viral Proteins Spectrometry Fluorescence Bacterial Proteins Protein Domains Immunoglobulin G Antibody Formation Spectroscopy Fourier Transform Infrared Toxicity Tests Chromatography Gel Animals Cytokines Electrophoresis Polyacrylamide Gel Female |
| Zdroj: | International journal of biological macromolecules. 190 |
| ISSN: | 1879-0003 |
| Popis: | Zika virus (ZIKV) induces neurological and autoimmune complications such as microcephaly and Guillain-Barre syndrome. Effective vaccines are necessary to prevent the ZIKV infection. E protein of ZIKV is responsible for virus attachment, entry, and fusion. The domain III of E protein (EDIII) contains the neutralizing epitopes and is ideal to act as an antigen for ZIKV vaccine. However, EDIII is poorly immunogenic. CRM |
| Databáze: | OpenAIRE |
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