| Autor: |
Nicolas, Kieffer, Laurent, Poirel, Claudine, Fournier, Brad, Haltli, Russel, Kerr, Patrice, Nordmann |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Frontiers in Microbiology |
| ISSN: |
1664-302X |
| Popis: |
The gene encoding the metallo-β-lactamase (MβL) PAN-1 was identified in the genome of the environmental Gram-negative species Pseudobacteriovorax antillogorgiicola. PAN-1 shares 57% amino-acid identity with the acquired MβL SPM-1, its closest relative. Kinetic parameters performed on purified PAN-1 showed it displayed a hydrolytic activity toward most β-lactams including carbapenems but spared cefepime and aztreonam. These results further highlight that environmental bacterial species may be reservoirs of MβL encoding genes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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