| Autor: |
Tao, Chen, Yucheng, Xue, Shengdong, Wang, Jinwei, Lu, Hao, Zhou, Wenkan, Zhang, Zhiyi, Zhou, Binghao, Li, Yong, Li, Zenan, Wang, Changwei, Li, Yinwang, Eloy, Hangxiang, Sun, Yihang, Shen, Mohamed Diaty, Diarra, Chang, Ge, Xupeng, Chai, Haochen, Mou, Peng, Lin, Xiaohua, Yu, Zhaoming, Ye |
| Rok vydání: |
2022 |
| Zdroj: |
Bioactive materials. 23 |
| ISSN: |
2452-199X |
| Popis: |
Insufficient infiltration of T cells severely compromises the antitumor efficacy of adoptive cell therapy (ACT) against solid tumors. Here, we present a facile immune cell surface engineering strategy aiming to substantially enhance the anti-tumor efficacy of Th9-mediated ACT by rapidly identifying tumor-specific binding ligands and improving the infiltration of infused cells into solid tumors. Non-genetic decoration of Th9 cells with tumor-targeting peptide screened from phage display not only allowed precise targeted ACT against highly heterogeneous solid tumors but also substantially enhanced infiltration of CD8 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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