[The clinical significance of MDR-1 gene expression in the hemopoietic cells of patients with acute leukemias in different phases of the disease]
| Autor: | T V, Bykova, A A, Sominskaia, A Iu, Zaritskiĭ, I Iu, Stiuf, B V, Medvedeva, N A, Anikina, B V, Afanas'ev |
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| Rok vydání: | 1998 |
| Předmět: |
Leukemia
Myeloid Acute Time Factors Drug Resistance Neoplasm Gene Expression Regulation Leukemic Antineoplastic Combined Chemotherapy Protocols Remission Induction Humans Bone Marrow Cells Genes MDR Precursor Cell Lymphoblastic Leukemia-Lymphoma Drug Resistance Multiple In Situ Hybridization Hematopoiesis |
| Zdroj: | Terapevticheskii arkhiv. 70(7) |
| ISSN: | 0040-3660 |
| Popis: | Analysis of cytostatic therapy effects on expression of gene MDR-1 in hemopoietic cells of patients with acute leukemia (AL) in complete clinicohematological remission (CCHR).The study included 48 AL patients. 27 of them were untreated, 25 were resistant to or had recurrent AL. 4 patients were followed up. Bone marrow mononuclear fraction was investigated. Expression of MDR-1 gene in the cells was evaluated at hybridization.High expression of MDR-1 gene occurred in leukemic blast cells either upon achievement of CCHR or at least 6 months after its onset. When using schemes of chemotherapy containing two potential inductors of gene MDR-1, expression of this gene was registered significantly more frequently than in using schemes based on one inducing drug (p0.05). Frequency of occurrence of enhanced expression of gene MDR-1 in leukemic blasts significantly correlated with frequency of CCHR (p0.05). Correlation between occurrence of the gene's expression in normal hemopoietic cells in CCHR and occurrence of early AL recurrences was not found.The findings may facilitate design of new AL treatment programs. |
| Databáze: | OpenAIRE |
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