| Autor: |
S-Abdul-Wahid, Fadilah, Raja-Sabudin, Raja-Zahratul-Azma, Chooi-Fun, Leong |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
The Malaysian journal of pathology. 28(1) |
| ISSN: |
0126-8635 |
| Popis: |
Intense myelofibrosis is rarely associated with de novo acute myeloid leukaemia (AML) except in acute megakaryoblastic leukaemia (AML-M7) where there is diffuse marrow fibrosis as a consequence of proliferation of neoplastic myeloid cells. AML associated with significant myelofibrosis developing both de novo or secondary to primary (idiopathic) myelofibrosis is characterised by a fulminant course and extremely poor prognosis, primarily due to treatment-resistant disease. The prognostic value of degree of marrow fibrosis in de novo AML has been poorly investigated. We describe a case of extensive myelofibrosis associated with acute erythroblastic leukaemia (AML-M6) that responded to induction therapy of the leukaemia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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