| Autor: |
Naoki, Kokudo, Mina, Okazoe, Joji, Takahashi, Kanako, Iseki, Kazuko, Yoshikawa, Hirosi, Imagawa, Toshihiro, Hashimoto, Masaaki, Noji, Akemi, Umeyama |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Natural product communications. 11(2) |
| ISSN: |
1934-578X |
| Popis: |
During the search for secondary metabolites with antiproliferative activity, six new lanostane triterpenoids, tyrosamic acids A-F (1-6) together with ten known compounds (7-16), were isolated from the fruiting body of Tyromyces sambuceus. Their structures were elucidated using MS analyses, extensive 2D-heteronuclear NMR data interpretation and the structure of 3 was further confirmed by single-crystal X-ray data analyses. All lanostane triterpenoids (1-16) possesses a carboxy group at C-20 position and their strength of antiproliferative activity was affected by the presence or absence of a hydroxy group at C-15 position and at the side chain. Four of the compounds (1, 6, 10, 14) showed antiproliferative activities against human cancer cell lines with IC₅₀ values of 16.8-48.3 µM (HL-60). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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