F-461, 3-diethylamino-2,2-dimethylpropyl 5-(p-nitrophenyl)-2-furoate hydrochloride, a new non-anticholinergic spasmolytic and gastric acid inhibitor
Autor: | M M, Goldenberg |
---|---|
Rok vydání: | 1976 |
Předmět: | |
Zdroj: | Archives internationales de pharmacodynamie et de therapie. 222(1) |
ISSN: | 0003-9780 |
Popis: | Compound F-461, 3-diethylamino-2,2-dimethylpropyl 5-(p-nitrophenyl)-2-furoate hydrochloride, was evaluated pharmacologically and was found to exert non-anticholinergic smooth muscle spasmolytic activity along the gastrointestinal tract of animals. F-461 was additionally discovered to inhibit gastric acid secretion and to prevent cold + restraint stress-induced ulcers. Local anesthesia, both surface and infiltration, was also elicited by F-461. The pharmacologic properties of F-461, as revealed in this study, are indicative of potential usefulness of this drug in the therapy of spastic colon and/or peptic ulcers. |
Databáze: | OpenAIRE |
Externí odkaz: |
načítá se...