[Influence of electroacupuncture of 'Dazhui' (EX-B2) and 'Mingmen' (GV4) on NR2B expression in anterior horns of spinal cord in rats with acute spinal cord injury]

Autor: Wen-Ci, Chen, Wen-Zhan, Tu, Jie, Hu, Rong, He, Xiao-Li, Huang, Guan-Hu, Yang, Song-He, Jiang
Rok vydání: 2019
Předmět:
Zdroj: Zhen ci yan jiu = Acupuncture research. 44(2)
ISSN: 1000-0607
Popis: To observe the influence of eletroacupuncture (EA) at "Dazhui" (EX-B2) and "Mingmen" (GV4) on expression of NR2B subunit of N-methyl-D-aspartate receptor (NMDA) in the injured anterior horn (AH) area of rats with acute spinal cord injury (SCI), so as to explore its mechanisms underlying improvement of neural repair.A total of 96 male Sprague-Dawley (SD) rats were randomly and equally divided into four groups: sham operation (sham), model, medication (Methyl-prednisone, MP) and EA (After SCI, the BBB scores at 6, 24 and 48 h were significantly decreased in the model group compared with those of the sham group (EA at EX-B2 and GV4 may inhibit the expression of NR2B mRNA and protein in acute SCI rats, which may contribute to its action in promoting nerve repair of the injured ventricolumna area of the thoracic spinal cord.
Databáze: OpenAIRE