| Autor: |
Danish, Saleheen, Wei, Zhao, Robin, Young, Christopher P, Nelson, WeangKee, Ho, Jane F, Ferguson, Asif, Rasheed, Kristy, Ou, Sylvia T, Nurnberg, Robert C, Bauer, Anuj, Goel, Ron, Do, Alexandre F R, Stewart, Jaana, Hartiala, Weihua, Zhang, Gudmar, Thorleifsson, Rona J, Strawbridge, Juha, Sinisalo, Stavroula, Kanoni, Sanaz, Sedaghat, Eirini, Marouli, Kati, Kristiansson, Jing, Hua Zhao, Robert, Scott, Dominique, Gauguier, Svati H, Shah, Albert Vernon, Smith, Natalie, van Zuydam, Amanda J, Cox, Christina, Willenborg, Thorsten, Kessler, Lingyao, Zeng, Michael A, Province, Andrea, Ganna, Lars, Lind, Nancy L, Pedersen, Charles C, White, Anni, Joensuu, Marcus, Edi Kleber, Alistair S, Hall, Winfried, März, Veikko, Salomaa, Christopher, O'Donnell, Erik, Ingelsson, Mary F, Feitosa, Jeanette, Erdmann, Donald W, Bowden, Colin N A, Palmer, Vilmundur, Gudnason, Ulf De, Faire, Pierre, Zalloua, Nicholas, Wareham, John R, Thompson, Kari, Kuulasmaa, George, Dedoussis, Markus, Perola, Abbas, Dehghan, John C, Chambers, Jaspal, Kooner, Hooman, Allayee, Panos, Deloukas, Ruth, McPherson, Kari, Stefansson, Heribert, Schunkert, Sekar, Kathiresan, Martin, Farrall, Philippe, Marcel Frossard, Daniel J, Rader, Nilesh J, Samani, Muredach P, Reilly |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Circulation. 135(24) |
| ISSN: |
1524-4539 |
| Popis: |
Common diseases such as coronary heart disease (CHD) are complex in etiology. The interaction of genetic susceptibility with lifestyle factors may play a prominent role. However, gene-lifestyle interactions for CHD have been difficult to identify. Here, we investigate interaction of smoking behavior, a potent lifestyle factor, with genotypes that have been shown to associate with CHD risk.We analyzed data on 60 919 CHD cases and 80 243 controls from 29 studies for gene-smoking interactions for genetic variants at 45 loci previously reported to be associated with CHD risk. We also studied 5 loci associated with smoking behavior. Study-specific gene-smoking interaction effects were calculated and pooled using fixed-effects meta-analyses. Interaction analyses were declared to be significant at aWe identified novel gene-smoking interaction for a variant upstream of the |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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