Photobiology of furocoumarins. Various types of crosslinking with DNA and their interference with the development of lambda phage

Autor:	Z, Hradecná, L, Kittler
Rok vydání:	1982
Předmět:	Viral Proteins Cross-Linking Reagents Ultraviolet Rays Furocoumarins DNA Viral Escherichia coli Adsorption Virus Replication Bacteriophage lambda
Zdroj:	Acta virologica. 26(5)
ISSN:	0001-723X
Popis:	It was shown that the multiplication of phage lambda was strongly suppressed by furocoumarins after irradiation with near ultraviolet light of 365 nm wavelength. Using xanthotoxin or angelicin there was a marked inhibition of the phage DNA injection and replication but adsorption was unaffected. This inhibition was attributed to various types of DNA crosslinking produced in the phage heads. Type I crosslink corresponded to covalent binding between adjacent sites in opposite strands of the double helix. Crosslink type II (hairpin crosslink) required a highly condensed DNA and corresponded to covalent binding between adjacent sites on double-helical segments of a folded DNA molecule. The relationships of the type I crosslinks to the DNA replication and of the type II crosslinks to DNA injection are being discussed. Like type II crosslinks, the nucleic acid--protein crosslinks hinder injection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::3e6fbf6023e50de65757bd3abf872bae https://pubmed.ncbi.nlm.nih.gov/6128899 Zobrazit plný text záznamu