| Autor: |
R, Hoffman, T, Papayannopoulou, S, Landaw, L R, Wasserman, Q B, DeMarsh, P, Chen, G, Stamatoyannopoulos |
| Rok vydání: |
1979 |
| Předmět: |
|
| Zdroj: |
Blood. 53(6) |
| ISSN: |
0006-4971 |
| Popis: |
Fetal hemoglobin was studied in 50 unselected patients with polycythemia vera with chemical determinations of Hb F and measurements of F-cell levels using fluorescent anti-Hb F antibodies. Although in the majority of the patients Hb F production did not differ from that in normal controls, in 20% of the patients F-cell values were above the normal range. There was no correlation between F-cell values and duration of disease, treatment modality, presence of myelofibrosis, or hematologic parameters at the time of study. In 5 of 50 patients 30%--45% of the erythrocytes contained Hb F; such striking elevations of F cells may reflect a distorted differentiation of erythroid precursor cells in certain patients with this disorder. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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