Normal T

Autor: Temel, Tirkes, Jacob R, Mitchell, Liang, Li, Xuandong, Zhao, Chen, Lin
Rok vydání: 2019
Předmět:
Zdroj: Abdom Radiol (NY)
ISSN: 2366-0058
Popis: OBJECTIVE: Determine normal T(1) and extracellular volume (ECV) of the pancreas in subjects with no pancreas disease and correlate with age and gender SUBJECTS AND METHODS: We imaged 120 healthy subjects (age range: 20-78 years) who are on annual screening with MRI/MRCP for the possibility of pancreatic cancer. Subjects had a predisposition to develop pancreatic cancer, but no history of pancreas disease or acute symptoms. Equal number (n=60) of subjects were scanned on either 1.5 T or 3 T scanner using dual flip angle spoiled gradient echo technique incorporating fat suppression and correction for B(1) field inhomogeneity. Optimization of imaging parameters were performed using a T(1) phantom. ECV was calculated using pre- and post-contrast T(1) of the pancreas and plasma. Regression analysis and Mann-Whitney tests were used for statistical analysis. RESULTS: Median T(1) on 1.5 T was 654 ms (IQR: 608-700); median T(1) on 3 T was 717 ms (IQR: 582-850); median ECV on 1.5 T was 0.28 (IQR: 0.21-0.33) and median ECV on 3 T was 0.25 (IQR: 0.19-0.28). Age had a mild positive correlation with T(1) (r= 0.24, p= 0.009), but not with ECV (r= 0.06, p=0.54). T(1) and ECV were similar in both genders (p >0.05). CONCLUSION: This study measured the median T(1) and ECV of the pancreas in subjects with no pancreas disease. Pancreas shows longer T(1) relaxation times in older population, whereas extracellular fraction remains unchanged. Median T(1) values were different between two magnet strengths; however, no difference was seen between genders and ECV fractions.
Databáze: OpenAIRE
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