| Autor: |
Benjamin, Spyrou, Ingebjørg N, Hungnes, Filipa, Mota, Jayanta, Bordoloi, Philip J, Blower, Jonathan M, White, Michelle T, Ma, Paul S, Donnelly |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Inorganic chemistry. 60(17) |
| ISSN: |
1520-510X |
| Popis: |
Alzheimer's disease (AD) is associated with the presence of amyloid plaques in the brain mainly comprised of aggregated forms of amyloid-β (Aβ). Molecules radiolabeled with technetium-99m that cross the blood-brain barrier (BBB) and selectively bind to Aβ plaques have the potential to assist in the diagnosis of AD using single-photon emission computed tomography imaging. In this work, three new tetradentate ligands of pyridyl, amide, amine and thiol donors, featuring a styrylpyridyl group that is known to interact with amyloid plaques, were prepared. The new ligands formed charge-neutral and lipophilic complexes with the [Tc═O] |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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