| Autor: |
Ren-Rui, Wu, Zhen-Yu, Xiao, Chen, Wang, Hua-Feng, Liu, Hao, Zhong, Feng, Li |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 19(4) |
| ISSN: |
1107-0625 |
| Popis: |
The purpose of this study was to evaluate the short- and long-term efficacy and toxicity of the humanized anti-epidermal growth factor receptor (EGFR) monoclonal antibody h-R3 when combined with radiotherapy for the treatment of locally advanced nasopharyngeal carcinoma (NPC).35 patients with stage III-IVb NPC with moderate- or strong-intensity EGFR expression were randomly divided into either a radiotherapy alone group or a group receiving radiotherapy combined with h-R3.The complete remission (CR) rates of the combination group at three time points were significantly higher (p0.05) than those of the radiotherapy alone group. Overall survival, 3-year local control rate, and no distant metastasis rate did not differ between the two groups. No severe toxicity was noticed.h-R3 is an agent with good safety profile which could help enhance the radiation antitumor effect in locally advanced NPC, but it did not seem to exhibit significant long-term efficacy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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