| Autor: |
Thomas K, van der Made, Michele, Fedecostante, Daniel, Scotcher, Amin, Rostami-Hodjegan, Javier, Sastre Toraño, Igor, Middel, Andries S, Koster, Karin G, Gerritsen, Vera, Jankowski, Joachim, Jankowski, Joost G J, Hoenderop, Rosalinde, Masereeuw, Aleksandra, Galetin |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Molecular pharmaceutics. 16(11) |
| ISSN: |
1543-8392 |
| Popis: |
Indoxyl sulfate (IxS), a highly albumin-bound uremic solute, accumulates in chronic kidney disease (CKD) due to reduced renal clearance. This study was designed to specifically investigate the role of human serum albumin (HSA) in IxS renal secretion via organic anion transporter 1 (OAT1) in a microfluidic system and subsequently apply quantitative translation of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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